Silica (silicon dioxide), as an important inorganic material, has extensive applications in the medical field. Based on the search results, I will provide a detailed introduction to the various aspects of silica's applications in the medical field.

Key Applications of Silica in Pharmaceuticals
1. Pharmaceutical Excipients
Silica is primarily used as the following excipients in pharmaceutical formulations:
Lubricant and Glidant: Leveraging its small particle size and large surface area, it improves the flowability and tableting properties of drug powders.
Anti-Adhesion Agent: Prevents drug particles from adhering to equipment during processing.
Adsorbent: Used in the granulation process of oil-based and extract-based drugs.
Stabilizer: Increases storage stability of drugs and prevents moisture absorption and agglomeration.
2. Digestive System Treatments
As the main ingredient in antacids, it is used to treat digestive system disorders such as hyperacidity and gastric ulcers. Its chemical inertness prevents adverse reactions with gastric acid, effectively neutralizing it.
3. Dermatological Applications
It is used in the preparation of anti-itch powders to relieve itchy skin symptoms. The silica component in silicone dressings forms a breathable barrier, maintaining a moderately moist environment on the wound surface. It inhibits scarring by reducing excessive keratinocyte proliferation and is commonly used in wound care for burns, postoperative incisions, and other wounds.
4. Dental Applications
Used as an abrasive for tooth whitening and cleaning
Used as a filler in dental materials

Research Progress on Silica as a Drug Carrier
1. Mesoporous Silica Nanocarriers
Featuring high surface area and tunable pore size, they can load anticancer drugs, antibiotics, and more.
Utilizing the Enhanced Permeability and Retention (EPR) effect for targeted delivery to tumor tissues
Can achieve sustained drug release, improving drug efficacy

2. Novel Nanosilica Materials
The material developed by the Chinese University of Hong Kong boasts a surface silanol group density more than four times that of conventional materials.
Exhibits strong adsorption capacity for drug molecules and possesses water affinity.
Can address the bioavailability issues of poorly soluble drugs and improve their water solubility

3. Historical Developments
In 1983, porous silica was first demonstrated as a drug delivery and stabilizer.
In 2001, MCM-41 was first used as a drug carrier for ibuprofen.
In 2003, particles with tunable size and surface functionality and controlled drug release were achieved.