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Hydrophobic gas-phase white carbon black: a

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In the era of precision medicine, hydrophobic vapor phase white carbon black has become an ideal carrier for drug delivery systems due to its biocompatibility and surface modifiability. Its applications cover multiple cutting-edge fields such as anti-cancer drugs, gene therapy, and vaccine development.


In terms of sustained release of anticancer drugs, continuous release of paclitaxel can be achieved through surface grafting of polyethylene glycol (PEG) chains. The core-shell structure carrier developed by the Fudan University team released only 15% in a phosphate buffer solution with pH 7.4 after 24 hours, while the release reached 85% in the tumor microenvironment (pH 5.0). Animal experiments showed that the vector reduced the tumor volume of the mouse breast cancer model by 72%, which was 31% higher than that of the free drug group.


In the field of gene therapy, gas-phase white carbon black serves as a protective shell for siRNA, which can resist RNase enzyme degradation. The LNP-SiO ₂ composite carrier developed by Johnson&Johnson still maintains 92% integrity of siRNA after 72 hours of storage in serum, compared to only 38% for traditional liposome carriers. This technology has entered phase I clinical trials for the treatment of hereditary transthyretin amyloidosis.


In the application of vaccine adjuvants, hydrophobic silica enhances immune response by activating TLR4 receptors. The COVID-19 vaccine adjuvant developed by Sinovac Biotech increased the antigen adsorption capacity from 0.5mg/mg to 2.1mg/mg, and the neutralizing antibody titer increased by 4.6 times compared to the aluminum adjuvant group. At present, this technology has obtained WHO pre certification and is supplied to 32 countries worldwide.

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