The application of silica in truck tire is a common concern of silica manufacturers and tire formula designers. Especially with the improvement of tire performance, tire formula designers are more and more interested in the application of silica in truck bias tire formula. This paper attempts to study the effect of different mixing processes of silica and surface pretreatment of silica on the performance of rubber compound, Explore the method of using silica to maximize the performance of truck bias tire in the most economical way. The research shows that the ideal blending ratio of silica can be determined based on the chemical properties of silica surface and carbon black surface. Take truck bias tire as an example, the optimum blending ratio of tread and carcass is 6-12 parts, This ratio can make the comprehensive performance of bias truck tire reach the best. Different mixing processes of silica have great influence on the performance of rubber compound. For example, if the surface of silica is not pretreated, the performance of silica can be better developed by using silica mother compound, while after the surface of silica is pretreated with Si-69, the mixing process can be simplified and the comprehensive performance of bias truck tire can reach the best