From a physiological point of view, polysiloxane is one of the polymers with the lowest known activity. Toxicological studies suggest that the low-boiling dimethicone is non-toxic and can be used in a large amount in foods, cosmetics, and pharmaceuticals. The animal lethal dose LD50 value (50% lethal dose) of dimethicone is 35g/Kg or more. This value is classified as non-toxic according to the toxicity of American Industrial Hygiene Association; there is no chronic poisoning problem and will not be absorbed by the digestive system. . No irritation to the membrane; low viscosity dimethicone has a slight irritation to the cornea but no damage.

It should be noted that the production method and production environment of silicone oil affect the purity of silicone oil (including low molecular weight siloxanes remaining in silicone oil, catalyst decomposition, neutralized residues and impurities introduced in the production environment). For pharmaceuticals, foods and cosmetics, special grade silicone oil should be used. At present, the state has promulgated the National Food Safety Standard for Food Additives Dimethicone and Its Emulsion (GB 30612-2014). It should be selected in accordance with national standards in the food field and passed the review by the State Food and Drug Administration. Production-grade special grade silicone oil.