Silica has significant application potential in the pharmaceutical industry. Its amorphous structure, good physiological inertness, adsorption, dispersibility and thickening properties make it have broad application prospects in the pharmaceutical field. The following is a detailed analysis of the application potential of silica in the pharmaceutical industry:

I. Application as a pharmaceutical excipient

Improved fluidity: 

In drugs such as Ranitidine and Pirenzepine, adding a small amount of fumed silica can change its fluidity, making the drug easier to process and prepare.

Dissolution rate regulation:

In drugs containing griseofulvin, adding a small amount of fumed silica can change its dissolution rate, that is, change the dispersibility and absorbability of the drug in water, thereby affecting the release rate and bioavailability of the drug.

Improved antistatic property:

In aspirin-containing powder, adding a small amount of fumed silica can change the antistatic property of the drug, preventing the drug from agglomerating or adsorbing impurities due to static electricity during processing and packaging.

Cell separation:

Use the surface of fumed silica to coat the appropriate monolayer material, and then disperse it in a polyvinyl pyrrolidone colloidal solution containing a variety of cells. Through centrifugation technology, the required cells can be quickly separated without contaminating the cells.

2. Application as a drug carrier

Fumed silica can be used as a carrier of active ingredients in drugs for the manufacture of tablets, pills, suppositories, etc. Its good dispersibility and adsorption properties help the drug to be evenly distributed and slowly released in the body, thereby improving the efficacy of the drug and reducing side effects.

3. Application in skin medicine

In skin medicine, fumed silica can use its high adsorption to adsorb microorganisms and microviruses, and its adsorption capacity exceeds the adsorption capacity of the corresponding adsorbents used in medicine. At the same time, the hydrophilicity of fumed silica can eliminate edema or reduce the secretion of wound inflammation, which helps repair and heal the skin.

4. Application in pesticides and herbicides

In pesticides and herbicides, Silica can be used as a dispersant and carrier to improve the dispersibility and adsorption of pesticides and herbicides, thereby extending their duration and improving their efficacy. For example, in herbicides such as cyclopentane/bensulfuron-methyl and pretilachlor/bensulfuron-methyl, the dispersibility and adsorption of fumed Silica can ensure that the herbicide has strong adsorption and a long duration.

5. Application in agricultural seed treatment

Silica can also be mixed with trace elements, growth regulators and mineral fertilizers to treat seeds, which can protect seeds from mechanical damage and moisture, increase seed germination rate and reduce fertilizer dosage, shorten maturity period and increase crop yield.

In summary, Silica has a wide range of application potential in the pharmaceutical industry. It can not only be used as a drug excipient to improve the physical properties and bioavailability of drugs, but also as a drug carrier and an active ingredient in skin medicine to play a therapeutic role. In addition, in pesticides, herbicides and agricultural seed treatment, Silica also shows good application prospects. With the continuous development of nanotechnology and the continuous expansion of application fields, the application of Silica in the pharmaceutical industry will be more extensive and in-depth.