Mesoporous silica nanoparticles (MSNs) are important porous materials with superior morphology, stable skeleton and excellent strength, which play an important role in adsorption, catalysis, photoluminescence, biomedicine and other fields. However, the drug loading rate of prototype MSNs is low, and compatibility and degradation problems exist in diagnosis and treatment and tissue engineering. The improvement of structure and physicochemical properties has driven it into innovative application fields.
Chen Aizheng's team from overseas Chinese University, Yusuke Yamauchi's team from Queensland University and Kevin C. - W. from Taiwan University Professor Wu cooperates to systematically review the key research situation and the latest breakthrough progress of MSNs in the past 20 years. Combining with supramolecular components, metal substances and coupling compounds, he focuses on the optimization of physical and chemical properties of MSNs by surface modification, siliceous framework modification and pore structure regulation, and elucidates the mechanism of reaction kinetics and influencing factors. In addition, the engineering application of advanced MSNs composites is prospected, and the problems to be solved and the multiple challenges to be faced are discussed.
Figure 1. Physical and chemical properties and key progress of Engineering MSNs
This paper describes the physical and chemical properties, breakthrough research progress and application of various innovative MSNs (Figure 1). A large number of studies have shown that MSNs have rich surface chemical properties, good colloidal stability, high dispersion, and special porous topological structure on the surface and inside, which has great potential for transformation. Firstly, this paper covers the key progress of MSNs in the past 20 years, and expounds the latest research and related situation of applying MSNs to clinical treatment. Then, compared with the general method and improvement scheme of MSNs synthesis process, the surface modification (using polymer, liposome, biofilm, protein coating, etc.), silicon skeleton modification (using organic components, metal substances, etc.) and pore structure regulation (such as cage, hollow, yolk shell, core shell, etc.) are discussed in detail to improve the morphology and physicochemical properties of MSNs, and also discussed Morphology changes including Janus structure and deformable solids.
In addition, this paper focuses on the performance comparison between innovative MSNs and prototype MSNs, including stability, biocompatibility and safety, degradability, etc. At the same time, the clinical trials and prospects of MSNs were critically discussed. Finally, based on the above theory, this paper looks forward to the engineering application of advanced MSNs composite materials, and discusses the problems to be solved and the multiple challenges to be faced.
This review paper was recently published in advanced materials. The first author of the paper is ranjith Kumar kankala, Ph.D. of Huaqiao University. The corresponding authors are Chen Aizheng, Professor of Huaqiao University, Yusuke Yamauchi, Professor of Queensland University and Kevin C. - W. Wu, Professor of Taiwan University.
Mater., 2020, DOI: 10.1002/adma.201907035
Tutor's introduction to Yusuke Yamauchi https://www.x-mol.com/university/factory/49986 home page of Chen Aizheng research group https://www.x-mol.com/groups/hqubiomat
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